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Registration Opens August 1, 2018

All available recordings of the the 2018 Conference (keynotes, panels, 90-minute workshops) are now available on our online store( Louie Tommy Hilfiger DuUwV9g


Wally Lamb

Wally Lamb is the author of six best-selling novels including and . Two of his novels were selected for Oprah’s Book Club.

Capturing the ‘I’ in Fiction and Nonfiction

Wednesday, February 14 6:30 PM

Jane Friedman

Jane Friedman is the co-founder and editor of , the essential publishing industry newsletter for authors, and is the former publisher of . She maintains an award-winning blog for writers at JaneFriedman.com (200,000 visits per month).

“Writing for Love (and Money)”

Thursday, February 15 2:00 PM

Rita Dove

Rita Dove, much beloved poet, is the former U.S. Poet Laureate, the first African American to hold the title, and recipient of the Pulitzer Prize. She is also an acclaimed lyricist.

“: Lyric, Narrative, and the Ties That Bind Them”

Thursday,February 15

John Vaillant

John Vaillant is the award-winning author of both fiction and nonfiction, including , a novel about Mexicans trying to cross the border. His books have all been bestsellers in Canada.

“Reverse Osmosis”

Friday, February 16

Jorge Volpi

Jorge Volpi is one of the most acclaimed writers of contemporary Mexican literature. He is the author of over 20 books, among which stands out , an international bestseller. He has received numerous awards and honors, among them a Guggenheim fellowship and the Planeta-Casa de America literary prize.

Real Fiction and Fictitious Realities.The Novel and the World

Simultaneous translation to English

Joseph Boyden

Joseph Boyden works with and writes about the First Nation people of Northern Ontario. His novels, including , have all won numerous awards.

“Creation Myth: One Writer’s Life in Three Simple Steps”

Saturday, February 17

Benjamin Alire Sáenz

Benjamin Alire Sáenz is an artist, poet, novelist, and author of children's books. His most recent book is a collection of poetry, .

“Living in the Wounds of a Nation (or at a time in my life when I would rather stay home and write in an office flooded in the light, why I cannot avert my eyes, why I cannot shut my mouth)”

Sunday, February 18
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These lines of evidence suggest a need to elucidate whether additive use of ARB is beneficial or not in the general practice of hypertensive chronic heart failure (CHF) patients treated with ACE inhibitors and/or β-blockers. In the supplemental benefit of ARB in hypertensive patients with stable heart failure using olmesartan (SUPPORT) trial, we thus aimed to examine whether a supplemental use of olmesartan provides beneficial impacts in patients with a broad spectrum of HF, who are treated with conventional therapies, namely with ACE inhibitors and/or β-blockers. 11

The SUPPORT trial was a prospective, randomized, open-label blinded endpoint study, 11 which was conducted according to the ethical principles described in Declaration of Helsinki. The study protocol was approved by the institutional ethics committees of the 17 participating institutions in the Tohoku District of Japan (Appendix). The primary objective of the study was to examine whether an additive treatment with an ARB, olmesartan, reduces the mortality and morbidity of hypertensive patients with stable CHF (NCT00417222). The inclusion criteria were designed to enroll hypertensive patients aged 20–79 with symptomatic CHF but in stable condition and were treated with ACE inhibitors and/or β-blockers, while the exclusion criteria were designed to exclude patients with substantive confounding medical conditions or an inability to meaningfully participate in the SUPPORT trial ( Table 1 ). Finally, a total of 1147 symptomatic CHF patients with a history of hypertension who met the inclusion and exclusion criteria and gave written informed consent for the trial were assigned to either the olmesartan or the control group according to a 1 : 1 ratio of olmesartan to control, through stratification by participating institute, sex and age between October 2006 and March 2010. The patients were followed up until the study ended on 31 March 2013 ( Figure 1 ). If contact could not be made at the end of the study, data of these patients were censored at the date when they were known to be alive last. Olmesartan was initiated at a dose of 5–10 mg/day, and then up titrated to 40 mg/day, if tolerable, in the olmesartan group, while no ARB use was allowed in the control group. The diagnosis of HF was made based on the criteria of the Framingham study 12 by an attending physician at each hospital. All physicians were encouraged to control blood pressure of the patients in each group according to the recommendations in the JNC7. 13 The primary endpoint was the composite of all-cause death, non-fatal acute myocardial infarction, non-fatal stroke, and worsening HF requiring hospitalization, while secondary endpoints consisted of the modes of death, hospitalization for cardiovascular reasons, surrogate markers for HF and development of cardiovascular disease, atrial fibrillation, diabetes, and renal dysfunction (see Log Set Kenneth Cole Reaction 4awY4
) .

Ready to go? Get to the heart of San Miguel de Allende with one of Lonely Planet's in-depth, award-winning guidebooks.

San Miguel de Allende Small-Group Food Tasting Tour with Lunch

Experience off-the-beaten path eateries and their colorful owners and staff, and regional delicacies. Walk away with an enriched understanding of San Miguel’s people and culture, a satisfied stomach and new insight to continue on your discovery of authentic San Miguel de Allende! This foodie walking tour features five food tasting locations carefully chosen to highlight the best regional flavors San Miguel has to offer. Enough for a satisfying lunch, you will enjoy a sampling of mouth-watering food at family-owned restaurants and stands and sip on refreshing local drinks. Learn about food from the local people and community, its history and deep cultural ties. Stops include mouth-watering Cochinita Pibil, delicious black mole, fresh ceviche, San Miguel’s best Churros and much more. All tastings are included in the ticket price.

San Miguel de Allende Evening Food Tour, Optional Wine Pairing

Theaim of the tour is to not only satisfy your stomach but quench yourthirst for knowledge. Between savoring delicious bites and tastings, you will explore the stunning architecture and learn about Mexican culture and traditions Delicious specialties served on the tour are: Aperi – Chef Mateo’s farm-to-table approach has changed the culinary landscape of San Miguel. La Azotea– Great rooftop tapas bar with amazing creations like their jicama shrimp taco. The Restaurant– Recognized as one of the top restaurants in San Miguel, it’sresponsible for making San Miguel a culinary destination with its seasonal dishes. El Pegaso- To try our national dish chile en nogada. 13 Ceilos- End the evening on a sweet note. * Please note that on Thursdays we visit the award winning restaurant Jacinto 1930 due to Thursday being Hamburger Night at The Restaurant

Canada de la Virgen Archaeological Site Full-Day Tour

The best way to visit the site of Cañada de la Virgen is with a team of archaeologists and anthropologists. The site is located just 25 kilometers West of San Miguel de Allende and you will see it along highly specialized guides who will share their knowledge of the Otomi people and of other cultures of the Bajio region, as well as the Mesoamerican cultures in general.You will be able to leisurely walk a total of approximately 3 kilometers (2 miles) within approximately 2 hours. This way your tour will encompass all of the archaeological site. You will leave with a more thorough knowledge of this wonderful, historical site.

San Miguel de Allende Half-Day Horseback Riding Adventure

The first part of our excursion takes us over the plains and amongst the cattle. After a short while we reach the edge of the canyon and begin a 40 minute descent to the bottom of the canyon, where we find a winding river named La Virgen which we will cross at several points. The views are truly breathtaking in every direction and the river crossings fun and exciting. Throughout the ride you will have the opportunity to gallop around.Half-way through the excursion there will be a stop for a short break to do a little bit of hiking and search for quartz filled geodes, or to simply relax along the edge of the river and take some fantastic photographs.After this rest stop, continue on your trusty steeds up-and-out of the canyon until reaching it's spectacular cliffs. Here you will make a pause on your horse to take some incredible photos. It is also here that you may wish to rappel off the sheer 120 foot-high cliff faces!For the grand finale the staff back at the ranch will have one of the most delicious organic ranch-style meals that you will ever experience. This authentic meal includes freshly hand-made tortillas, organic cheese, beans, quesadillas, nopales (cactus), rice, salad, guacamole salsa, fresh fruit among other traditional dishes.

Tacos and Tequila Food Walking Tour in San Miguel de Allende

Meet your guide at a central location in San Miguel to start your 3.5-hour food and cocktail walking tour. Satisfy your craving for good food with each tasty bite while quenching your thirst for knowledge — and the best cocktails. You’ll stop by six tasting locations, including family-owned eateries and food stands chosen by your guide to highlight local cuisine and drinks. Sip a mezcal cocktail made with tamarind paired with a mushroom taco; lndulge in a gourmet chicken taco invented by an award-winning chef ; eat at San Miguel busiest taco stand andexperience one of San Miguel oldest cantinas. Learn the historical significance of Mexican spirits and how to differentiate each one. Between mouthwatering tastings your informative guide will point out some of San Miguel’s must-see sights.

Leisurely Half Day Trail Riding in San Miguel de Allende

Your guide will provide a detailed western riding lesson on the commands to have a fun and safe trail riding experience. Have one cowboy for every two riders for communication and safety! Children (first time on a horse) under the ages of 13 can have their own personal cowboy leading them on a rope with their own horse. Start riding from "Ejido de Boca de la Canada" through the river which is totally awesome and the local horses are trained and sure footed! Then you ride pass a 300+ year old antique Otomi Chapel for a little history. Start climbing up the Canyon on easy trails (no ledges) to enjoy the beautiful views of the Canada de la Virgen. Stop for 15 minutes at a lookout above the canyon to take photos of you with your cameras! Customize your riding where it's appropriate for trotting, cantering or galloping with our experienced cowboys while others can continue walking to enjoy the spectacular views. Catch-up with each other on the trails! Stop halfway through the trail ride to stretch your legs and rest for as long as you like to enjoy the spectacular views of the Presa Allende and San Miguel de Allende. The bonus here is you never return back on the same trails for different views and terrain! See "other tour options" for your customized"Sunset" trail rides too! Provide you with a variety of different trails to customizethe various experienced and non-experienced level riders. For the more adventurous riders, your guide takes you deeper into the countryside for more galloping in "Ejido de Boca de la Canada"! Personalize your comfort and experience level of horseback riding. Always, riding with an English speaking guide for communication and practice your Spanish riding with the professional cowboys! Provide door to door pickup/drop-off for up to 8 riders gratis in a luxurious suburban. Mexicanauthentic ranch lunch is included served afterwards. Also, the local women can prepare you with vegetarian, gluten free and/or special dietary lunches in advanced.

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